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Growth factor-like domain : ウィキペディア英語版
Growth factor-like domain

A growth factor-like domain (GFLD) is a protein domain structurally related to epidermal growth factor, which has a high binding affinity for the epidermal growth factor receptor. As structural domains within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member of the heparin-binding class of GFLDs and may itself have growth factor function, particularly in promoting neuronal development.
==References==

* Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. (1999). Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. ''Nat Struct Biol'' 6(4):327-31.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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